EC Number | Application | Comment | Organism |
---|---|---|---|
2.1.1.63 | medicine | clonal selection of AGT mutants during trteatment with O6-benzylguanine plus an alkylator may produce resistance to this intervention in clinical settings | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.1.1.63 | G156C | mutant form expressed by the medulloblastoma cell line D283 MED, mutant enzyme is not easily inhibited by O6-benzylguanine | Homo sapiens |
2.1.1.63 | K165T | mutant form expressed by the medulloblastoma cell line D341 MED, mutant enzyme is not easily inhibited by O6-benzylguanine | Homo sapiens |
2.1.1.63 | Y114F | mutant form expressed by the medulloblastoma cell line Daoy, mutant enzyme is not easily inhibited by O6-benzylguanine | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.63 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.1.63 | medulloblastoma cell | D283 MED, D341 MED and Daoy | Homo sapiens | - |